Article
A quantitative linkage score for an association study following a linkage analysis.
BMC genetics - 20 Jan 2006
Wang Tao, Elston Robert C
Abstract excerpt
BACKGROUND: Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions arise in the design and the resulting inference at the association stage of this sequential...
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