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Article

Accumulation of class I mutant p53 and apoptosis induced by carboplatin in a human glioma cell line.

Brain tumor pathology - 1 Jan 1998

Hamada Y, Mizoguchi M, Suzuki S O, Iwaki T

Abstract excerpt

Following DNA damage, wild-type p53 increases and mediates the multiple cellular responses for the repair of DNA damage or apoptosis. Inactivation of p53 by single-amino-acid substitutions contributes to the malignant phenotype and confers resistance to therapy. Among tumor-derived p53 mutants, class I mutants still retain a native-like three-dimensional structure, whereas class II mutants have unfolded...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 10328543
DOI: 10.1007/BF02478887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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