Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal.

Molecular cancer research : MCR - 1 Feb 2009

Batista Luis F Z, Roos Wynand P, Kaina Bernd, Menck Carlos F M

Abstract excerpt

The p53 protein is a key regulator of cell responses to DNA damage, and it has been shown that it sensitizes glioma cells to the alkylating agent temozolomide by up-regulating the extrinsic apoptotic pathway, whereas it increases the resistance to chloroethylating agents, such as ACNU and BCNU, p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to bcl-2 Homologous Antagonist-Killer Protein
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fas-Associated Death Domain Protein

Share to In Situ Nick-End Labeling

Share to Proto-Oncogene Proteins c-bcl-2

Share to Pyrimidine Dimers

Share to RNA, Neoplasm

Source

Identifiers

PMID: 19208740
DOI: 10.1158/1541-7786.MCR-08-0428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19208740-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal.PMID 19208740Read ↗

Role of p53 mutations in the radiosensitivity status of tumor cells.Semantic proximity Read ↗

Radiation-Induced Caspase-8 Mediates p53-Independent Apoptosis in Glioma CellsSemantic proximity Read ↗

p53 regulation of DNA excision repair pathways.Semantic proximity Read ↗

Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalitiesSemantic proximity Read ↗

Bak and Mcl-1 are essential for Temozolomide induced cell death in human gliomaSemantic proximity Read ↗

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.Semantic proximity Read ↗

The Circadian Gene Per1 Plays an Important Role in Radiation-Induced Apoptosis and DNA Damage in GliomaSemantic proximity Read ↗

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.Semantic proximity Read ↗

Radiation-induced apoptosis in the adult central nervous system is p53-dependentSemantic proximity Read ↗

Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis.Semantic proximity Read ↗

Cellular aspects of photocarcinogenesis.Semantic proximity Read ↗

Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.