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Article

Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.

Cancer research - 1 Oct 2005

Tomicic Maja T, Christmann Markus, Kaina Bernd

Abstract excerpt

The anticancer drug topotecan belongs to the group of topoisomerase I (topo I) inhibitors. In the presence of topotecan, topo I cleaves the DNA but is unable to religate the single-strand break. This leads to stabilization of topo I-DNA-bound complexes and the accumulation of DNA strand breaks th...

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Identifiers

PMID: 16204064
DOI: 10.1158/0008-5472.CAN-05-0266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16204064-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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