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Article

Proteasome Inhibitors Induce p53/p21-Independent Apoptosis in Human Glioma Cells

1 Jan 1999

Abstract excerpt

The proteasome is a multiprotein complex involved in the degradation of ubiquitinated proteins. Three proteasome inhibitors, calpain inhibitor I, lactacystin and MG132, induced apoptosis in several human malignant glioma cell lines. Although proteasome inhibitors induced p53 accumulation in a cell line retaining wild-type p53 activity, p53 activity was dispensable for apoptosis since transdominant-negative p53...

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PMID: 10494025
DOI: 10.1159/000016308

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