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Article

Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis.

Journal of the American College of Cardiology - 21 Feb 2012

Ferguson Jane F, Hinkle Christine C, Mehta Nehal N, Bagheri Roshanak, Derohannessian Stephanie L, Shah Rhia, Mucksavage Megan I, Bradfield Jonathan P, Hakonarson Hakon, Wang Xuexia, Master Stephen R, Rader Daniel J, Li Mingyao, Reilly Muredach P

Abstract excerpt

OBJECTIVES: This study sought to examine the role of lipoprotein-associated phospholipase A₂ (Lp-PLA₂/PLA2G7) in human inflammation and coronary atherosclerosis. BACKGROUND: Lp-PLA₂ has emerged as a potential therapeutic target in coronary heart disease. Data supporting Lp-PLA₂ are indirect and confounded by species differences; whether Lp-PLA₂ is causal in coronary heart disease remains in question. METHODS: We...

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PMID: 22340269
DOI: 10.1016/j.jacc.2011.11.019
PMCID: PMC3285416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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