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Article

The N-terminal capping propensities of the D-helix modulate the allosteric activation of the Escherichia coli cAMP receptor protein.

The Journal of biological chemistry - 16 Nov 2012

Yu Shaoning, Maillard Rodrigo A, Gribenko Alexey V, Lee J Ching

Abstract excerpt

Transduction of biological signals at the molecular level involves the activation and/or inhibition of allosteric proteins. In the transcription factor cAMP receptor protein (CRP) from Escherichia coli, the allosteric activation, or apo-holo transition, involves rigid body motions of domains and structural rearrangements within the hinge region connecting the cAMP- and DNA-binding domains. During this apo-holo...

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Identifiers

PMID: 23035121
DOI: 10.1074/jbc.M112.404806
PMCID: PMC3501046

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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