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Article

The Prognostic Relevance of p16 Inactivation in Head and Neck Cancer

2 Nov 2006

Abstract excerpt

The inactivation of the tumor suppressor gene p16 plays an important role in the development of malignant tumors. p16 loss can result from point mutations, loss of heterozygosity (LOH) or methylation of the promoter region. A total of 67 samples of tumor tissue from squamous cell carcinoma of the oral cavity, the pharynx and the larynx were analyzed for an inactivation of p16. The results of the...

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PMID: 17085950
DOI: 10.1159/000096714

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