Article
Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.
Annals of neurology - 1 May 1999
Krüger R, Vieira-Saecker A M, Kuhn W, Berg D, Müller T, Kühnl N, Fuchs G A, Storch A, Hungs M, Woitalla D, Przuntek H, Epplen J T, Schöls L, Riess O
Abstract excerpt
Parkinson's disease (PD) is one of the most common neurodegenerative disorders affecting about 1% of Western populations older than age 50. The pathological hallmark of PD are Lewy bodies, that is, intracytoplasmic inclusion bodies in affected neurons of the substantia nigra. Recently, alpha-synuclein (alpha-SYN) has been identified as the main component of Lewy bodies in sporadic PD, suggesting involvement in...
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