Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.

Annals of neurology - 1 May 2001

Khan N, Graham E, Dixon P, Morris C, Mander A, Clayton D, Vaughan J, Quinn N, Lees A, Daniel S, Wood N, de Silva R

Abstract excerpt

A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 4

Share to Genetic Markers

Share to Nerve Tissue Proteins

Share to Parkinson Disease

Share to Polymorphism, Genetic

Share to Synucleins

Source

Identifiers

PMID: 11357958

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.PMID 11357958Read ↗

Apolipoprotein E epsilon4 allele frequency is increased in Parkinson's disease only with co-existing Alzheimer pathology.Semantic proximity Read ↗

Apolipoprotein E genotype in familial Parkinson's disease. The French Parkinson's Disease Genetics Study Group.Semantic proximity Read ↗

Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.Semantic proximity Read ↗

Frequency of the apolipoprotein E epsilon 4 allele in a case-control study of early onset Parkinson's disease.Semantic proximity Read ↗

Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease.Semantic proximity Read ↗

The apolipoprotein E epsilon 4 allele in Parkinson's disease with Alzheimer lesions.Semantic proximity Read ↗

APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease.Semantic proximity Read ↗

Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.Semantic proximity Read ↗

A large study reveals no association between APOE and Parkinson's disease.Semantic proximity Read ↗

Genetic variants of α-synuclein are not associated with essential tremor.Semantic proximity Read ↗

Association between apolipoprotein E genotypes and Parkinson's disease.Semantic proximity Read ↗

No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.