Article
An E box comprises a positional sensor for regional differences in skeletal muscle gene expression and methylation.
Developmental biology - 1 Sept 1999
Ceccarelli E, McGrew M J, Nguyen T, Grieshammer U, Horgan D, Hughes S H, Rosenthal N
Abstract excerpt
To dissect the molecular mechanisms conferring positional information in skeletal muscles, we characterized the control elements responsible for the positionally restricted expression patterns of a muscle-specific transgene reporter, driven by regulatory sequences from the MLC1/3 locus. These sequences have previously been shown to generate graded transgene expression in the segmented axial muscles and their...
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