Article
Proximal sequences of the aldolase A fast muscle-specific promoter direct nerve- and activity-dependent expression in transgenic mice.
The Journal of biological chemistry - 12 Jun 1998
Spitz F, De Vasconcelos Z A, Châtelet F, Demignon J, Kahn A, Mira J C, Maire P, Daegelen D
Abstract excerpt
Muscle activity is known to modulate the muscle fiber phenotype. Changes in muscle activity (normal or experimentally induced) lead to modifications of the expression status of several muscle-specific genes. However, the transcription regulatory elements involved in the adaptative response are ma...
Topics
- Animals
- Crosses, Genetic
- Fructose-Bisphosphate Aldolase
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Immunohistochemistry
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Muscle Contraction
- Muscle Denervation
- Muscle Fibers, Fast-Twitch
- Muscle, Skeletal
- Phenotype