Article
Natural variation in translational activities of the 5' nontranslated RNAs of hepatitis C virus genotypes 1a and 1b: evidence for a long-range RNA-RNA interaction outside of the internal ribosomal entry site.
Journal of virology - 1 Jun 1999
Honda M, Rijnbrand R, Abell G, Kim D, Lemon S M
Abstract excerpt
The 5' nontranslated RNA (5'NTR) of a genotype 1b hepatitis C virus (HCV-N) directs cap-independent translation of the HCV-N polyprotein with about twofold less efficiency than the 5'NTR of a genotype 1a virus under physiologic conditions (Hutchinson strain, or HCV-H) (M. Honda et al., Virology 222:31-42, 1996). Here, we show by mutational analysis that substitution of the AG dinucleotide sequence at nucleotides...
Topics
- 5' Untranslated Regions
- Animals
- Base Sequence
- Capsid
- Genotype
- Hepacivirus
- Mice
- Molecular Sequence Data
- Potassium Chloride
- Protein Biosynthesis
- RNA, Viral
- Ribosomes