Article
Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice.
The American journal of pathology - 1 Apr 1999
Altavilla G, Trabanelli C, Merlin M, Caputo A, Lanfredi M, Barbanti-Brodano G, Corallini A
Abstract excerpt
To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridization revealed that the transgene is stably maintained in all organs of transgenic mice as a tandem...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.