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Article

Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype.

PloS one - 1 Jan 2017

Chang Hsuen-Wen, Lin Zih-Miao, Wu Min-Ju, Wang Li-Yu, Chow Yen-Hung, Jiang Shih Sheng, Ch'ang Hui-Ju, Chang Vincent Hs

Abstract excerpt

Developing lung cancer in mouse models that display similarities of both phenotype and genotype will undoubtedly provide further and better insights into lung tumor biology. Moreover, a high degree of pathophysiological similarity between lung tumors from mouse models and their human counterparts will make it possible to use these mouse models for preclinical tests. Ovine pulmonary adenocarcinomas (OPAs) present...

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Identifiers

PMID: 28419107
DOI: 10.1371/journal.pone.0175586
PMCID: PMC5395147

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