Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes.

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Article

Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes.

Cancer research - 15 Nov 1993

Corallini A, Altavilla G, Pozzi L, Bignozzi F, Negrini M, Rimessi P, Gualandi F, Barbanti-Brodano G

Abstract excerpt

The human immunodeficiency virus tat protein, a transactivator of viral and cellular genes, is suspected to be involved in the pathogenesis of acquired immunodeficiency syndrome-associated tumors. We report that transgenic mice carrying a recombinant DNA containing BK virus early region and the h...

Topics

Adenocarcinoma
Animals
BK Virus
Carcinoma
Carcinoma, Squamous Cell
Fibrosarcoma
Genes, tat
Mice
Mice, Transgenic
Papillomavirus Infections
Phenotype
Skin Neoplasms
Tumor Virus Infections

Source

Open in PubMed

Identifiers

PMID: 8221699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8221699-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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