Article
Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression.
The Journal of pathology - 1 Oct 1998
Hall A P, Irvine J, Blyth K, Cameron E R, Onions D E, Campbell M E
Abstract excerpt
In order to investigate the role that the human T-lymphotropic virus type I (HTLV-I) tax oncogene plays in apoptosis and transformation in vivo, four lines of HTLV-I tax transgenic mice were generated under the regulatory control of the CD3-epsilon promoter-enhancer sequence. These mice develop a variety of phenotypes including mesenchymal tumours, which develop at wound sites, and salivary and mammary adenomas....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.