Article
QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice.
Pediatric research - 1 May 1999
Bevilacqua L M, Maguire C T, Seidman J G, Seidman C E, Berul C I
Abstract excerpt
Patients with familial hypertrophic cardiomyopathy (FHC) are at risk for ventricular arrhythmias and sudden death. Regional variability in the QT interval [QT dispersion (QTd)] is significantly increased in humans with FHC and ventricular arrhythmias. A mouse model of FHC resulting from a mutation in the alpha-myosin heavy-chain (Arg403Gln) was used to study the electrophysiologic phenotype of this disease....
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