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Article

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2017

Toib Amir, Zhang Chen, Borghetti Giulia, Zhang Xiaoxiao, Wallner Markus, Yang Yijun, Troupes Constantine D, Kubo Hajime, Sharp Thomas E, Feldsott Eric, Berretta Remus M, Zalavadia Neil, Trappanese Danielle M, Harper Shavonn, Gross Polina, Chen Xiongwen, Mohsin Sadia, Houser Steven R

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac diseases and among the leading causes of sudden cardiac death (SCD) in the young. The cellular mechanisms leading to SCD in HCM are not well known. Prolongation of the action potential (AP) duration (APD) is a common feature predisposing hypertrophied hearts to SCD. Previous studies have explored the roles of inward Na+ and Ca2+ in the...

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Identifiers

PMID: 28646025
DOI: 10.1152/ajpheart.00167.2017
PMCID: PMC5625176

Genes

SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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