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Article

In vivo studies of Scn5a+/- mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities.

Journal of electrocardiology - 1 Jan 2000

Martin Claire A, Zhang Yanmin, Grace Andrew A, Huang Christopher L-H

Abstract excerpt

OBJECTIVES: We investigate the extent to which the electrocardiographic (ECG) properties of intact Scn5a+/- mice reproduce the corresponding clinical Brugada syndrome phenotype and use this model to investigate the role of conduction and repolarization abnormalities in the arrhythmogenic mechanism. METHODS AND RESULTS: The ECGs were obtained from anesthetized wild-type and Scn5a+/- mice, before and after...

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Identifiers

PMID: 20638671
DOI: 10.1016/j.jelectrocard.2010.05.015
PMCID: PMC3712183

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Source receipt: pubmed, retrieved 7 Sept 2026.

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