Article
Antibody Binding Selectivity: Alternative Sets of Antigen Residues Entail High-Affinity Recognition.
PloS one - 1 Jan 2015
Nominé Yves, Choulier Laurence, Travé Gilles, Vernet Thierry, Altschuh Danièle
Abstract excerpt
Understanding the relationship between protein sequence and molecular recognition selectivity remains a major challenge. The antibody fragment scFv1F4 recognizes with sub nM affinity a decapeptide (sequence 6TAMFQDPQER15) derived from the N-terminal end of human papilloma virus E6 oncoprotein. Using this decapeptide as antigen, we had previously shown that only the wild type amino-acid or conservative...
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