Article
Asparagine-344 is a key residue for ligand binding in keratinocyte growth factor receptor.
Biochemistry - 10 Dec 1996
Gray T E, Eisenstein M, Yayon A, Givol D
Abstract excerpt
The membrane proximal, immunoglobulin- (Ig-) like domain 3 of KGFR shows significant sequence similarity to the Ig light chain variable (V) domain. According to our model, based on this similarity, the F-G loop in KGFR corresponds to the complementarity determining region (CDR) 3 of the Ig V doma...
Topics
- Amino Acid Sequence
- Asparagine
- Binding Sites
- Blotting, Western
- Chromatography, Affinity
- Cross-Linking Reagents
- DNA Primers
- Fibroblast Growth Factors
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation