Article
Evidence that the Igkappa gene MAR regulates the probability of premature V-J joining and somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 1999
Yi M, Wu P, Trevorrow K W, Claflin L, Garrard W T
Abstract excerpt
The Igkappa gene contains an evolutionarily conserved nuclear matrix association region (MAR) adjacent to the intronic enhancer. To test for the function of this MAR, we created mouse lines with a targeted MAR deletion. In MAR knockout animals, the immune system was normal in nearly all respects, including the distributions of various B cell populations and Ab levels. However, in pro-B cells, enhanced...
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