Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS.

Neurology - 22 Apr 1999

Weinshenker B G, Hebrink D, Wingerchuk D M, Klein C J, Atkinson E, O'Brien P C, McMurray C T

Abstract excerpt

We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to TNF gene
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Sclerosis

Share to Mutation

Share to Receptors, Tumor Necrosis Factor

Source

Identifiers

PMID: 10227645
DOI: 10.1212/wnl.52.7.1500

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS.PMID 10227645Read ↗

Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis.Semantic proximity Read ↗

Genetic variation in the tumor necrosis factor alpha gene and the outcome of multiple sclerosis.Semantic proximity Read ↗

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.Semantic proximity Read ↗

Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis.Semantic proximity Read ↗

A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis.Semantic proximity Read ↗

TNFRSF1A R92Q mutation in association with a multiple sclerosis-like demyelinating syndrome.Semantic proximity Read ↗

Association of IL2RA polymorphisms with susceptibility to multiple sclerosis is not explained by missense mutations in IL2RA.Semantic proximity Read ↗

CTLA4 is associated with susceptibility to multiple sclerosis.Semantic proximity Read ↗

Association of a tumor necrosis factor alpha polymorphism with MS susceptibility.Semantic proximity Read ↗

Tumor necrosis factor polymorphism in multiple sclerosis: no additional association independent of HLA.Semantic proximity Read ↗

TNFRSF1A coding variants in multiple sclerosis.Semantic proximity Read ↗

Genetic variation in the B7-1 gene in patients with multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.