Article
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.
Nature - 23 Aug 2012
Gregory Adam P, Dendrou Calliope A, Attfield Kathrine E, Haghikia Aiden, Xifara Dionysia K, Butter Falk, Poschmann Gereon, Kaur Gurman, Lambert Lydia, Leach Oliver A, Prömel Simone, Punwani Divya, Felce James H, Davis Simon J, Gold Ralf, Nielsen Finn C, Siegel Richard M, Mann Matthias, Bell John I, McVean Gil, Fugger Lars
Abstract excerpt
Although there has been much success in identifying genetic variants associated with common diseases using genome-wide association studies (GWAS), it has been difficult to demonstrate which variants are causal and what role they have in disease. Moreover, the modest contribution that these variants make to disease risk has raised questions regarding their medical relevance. Here we have investigated a single...
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