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Article

Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response

20 Mar 2009

Abstract excerpt

BACKGROUND: The molecular determinants of the severity and persistence of allergic asthma remain poorly understood. Suppressor of cytokine signalling 1 (SOCS1) is a negative regulator of IL-4-dependent pathways in vitro and might therefore control T-helper type 2 (Th2) immunity associated traits, such as IgE levels, mucin production, IL-5 and IL-13 induction, and eosinophilic mucosal inflammation, which are...

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PMID: 19309352
DOI: 10.1111/j.1365-2222.2009.03217.x

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