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Article

The role of IFN in respiratory syncytial virus pathogenesis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2002

Durbin Joan E, Johnson Teresa R, Durbin Russell K, Mertz Sara E, Morotti Rafaella A, Peebles R Stokes, Graham Barney S

Abstract excerpt

Formalin-inactivated respiratory syncytial virus (RSV) vaccine preparations have been shown to cause enhanced disease in naive hosts following natural infection. In this study we demonstrate a similar pattern of enhanced disease severity following primary RSV infection of IFN-nonresponsive STAT1(-/-) mice. STAT1(-/-) mice showed markedly increased illness compared with wild-type BALB/c animals following RSV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11884466
DOI: 10.4049/jimmunol.168.6.2944

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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