Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.

Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007

Ramsauer Katrin, Farlik Matthias, Zupkovitz Gordin, Seiser Christian, Kröger Andrea, Hauser Hansjörg, Decker Thomas

Abstract excerpt

A subgroup of genes induced by IFN-gamma requires both STAT1 and IRF1 for transcriptional activation. Using WT, stat1(-/-), or irf1(-/-) cells, we analyzed the changes induced by IFN-gamma in gbp2 promoter chromatin. STAT1 associated with the promoter independently of IRF1 and played an essential role in the ordered recruitment of the coactivator/histone acetyl transferase CREB-binding protein (CBP) and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Genes, Regulator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Interferon-gamma

Share to Interferon Regulatory Factor-1

Share to Phosphoserine

Share to RNA Polymerase II

Share to STAT1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 17293456
DOI: 10.1073/pnas.0610944104
PMCID: PMC1815270

Genes

STAT1
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.PMID 17293456Read ↗

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responsesSemantic proximity Read ↗

Brahma-Related Gene 1-Dependent STAT3 Recruitment at IL-6-Inducible GenesSemantic proximity Read ↗

A Comprehensive Profile of ChIP-Seq-Based STAT1 Target Genes Suggests the Complexity of STAT1-Mediated Gene Regulatory MechanismsSemantic proximity Read ↗

Epigenetic signals that direct cell type–specific interferon beta response in mouse cellsSemantic proximity Read ↗

Properties of STAT1 and IRF1 enhancers and the influence of SNPs.Semantic proximity Read ↗

The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid InhibitionSemantic proximity Read ↗

Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes.Semantic proximity Read ↗

STAT2 and IRF9Semantic proximity Read ↗

T helper type 1–specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-γ promoter are Stat4 dependentSemantic proximity Read ↗

Epigenetic signals that direct cell type specific interferon beta response in mouse cellsSemantic proximity Read ↗

Contribution of a TANK-Binding Kinase 1–Interferon (IFN) Regulatory Factor 7 Pathway to IFN-γ-Induced Gene ExpressionSemantic proximity Read ↗

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.