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Article

IFN-γ Influences Epithelial Antiviral Responses via Histone Methylation of the RIG-I Promoter

8 May 2017

Abstract excerpt

The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T-helper cell type 1 response in early life may lead to these aberrant antiviral responses. To study the development of long-term dysregulation of innate responses, which is a hallmark of asthma, we investigated whether the inflammatory environment of the...

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PMID: 28481620
DOI: 10.1165/rcmb.2016-0392oc

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