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Article

Genetic determinants of 5-lipoxygenase transcription.

International archives of allergy and immunology - 1 Jan 2000

Drazen J M, Silverman E S

Abstract excerpt

BACKGROUND: 5 Lipoxygenase (5-LO) is a critical enzyme in the production of the leukotrienes. We have identified a series of mutations in the 5-LO gene that modify gene transcription. These mutations consist of addition of an Sp-1 binding motif (-GGGCGG-) or deletion of one or two Sp-1 binding mo...

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PMID: 10224409
DOI: 10.1159/000024098

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10224409-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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