Article
Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants.
American journal of respiratory cell and molecular biology - 1 Aug 1998
Silverman E S, Du J, De Sanctis G T, Rådmark O, Samuelsson B, Drazen J M, Collins T
Abstract excerpt
5-Lipoxygenase (5-LO), an enzyme essential for the formation of leukotrienes, is functionally modulated by a number of mechanisms, including transcriptional controls. The 5-LO promoter has a unique G+C-rich sequence, located between 176 and 147 base pairs upstream of the ATG translation start site, which contains five tandem Sp1 (a zinc-finger transcription factor) consensus binding sites overlapping five tandem...
Topics
- Animals
- Arachidonate 5-Lipoxygenase
- Binding Sites
- Cell Line
- DNA Footprinting
- DNA-Binding Proteins
- Drosophila
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- Recombinant Proteins
- Sp1 Transcription Factor
- Transcription Factors
- Transcriptional Activation