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Article

Regulatory mechanisms of human T cell IL-5 synthesis: differential roles of the proximal promoter-binding proteins in IL-5 gene transcription.

International archives of allergy and immunology - 1 Jan 2000

Mori A, Kaminuma O, Ogawa K, Kobayashi N, Akiyama K, Okudaira H

Abstract excerpt

BACKGROUND: IL-5 is crucially involved in eosinophilic inflammation. We have previously reported that IL-5 synthesis by atopic and nonatopic asthmatics is significantly enhanced compared to control subjects. T cell IL-5 synthesis is regulated at the transcriptional level. The proximal human IL-5 promoter (-62 to -46) homologous to the conserved lymphokine element 0 (CLE0) is essential for activation-induced gene...

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Source

Identifiers

PMID: 10224408
DOI: 10.1159/000024097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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