Adaptive reversion of a frameshift mutation in Escherichia coli.

Abstract excerpt

Mutation rates are generally thought not to be influenced by selective forces. This doctrine rests on the results of certain classical studies of the mutations that make bacteria resistant to phages and antibiotics. We have studied a strain of Escherichia coli which constitutively expresses a lacI-lacZ fusion containing a frameshift mutation that renders it Lac-. Reversion to Lac+ is a rare event during...

Topics

• Adaptation, Biological
• Alleles
• Escherichia coli
• Frameshift Mutation
• Gene Expression Regulation, Bacterial
• Genes, Bacterial
• Genetic Variation
• Lac Operon
• Lactose
• Tryptophan