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Article

Different characteristics distinguish early versus late arising adaptive mutations in Escherichia coli FC40.

Mutation research - 20 Feb 2001

Powell S C, Wartell R M

Abstract excerpt

The Escherichia coli strain FC40 has frequently been employed to investigate the mechanism of adaptive mutations. The strain cannot utilize lactose due to a +1 frameshift mutation that reduces beta-galactosidase to about 1% of normal levels. Cells undergo a high rate of mutation from Lac- to Lac+ when cells are grown with lactose as the sole energy source. Almost all Lac+ colonies arising 3-6 days after plating...

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PMID: 11166039
DOI: 10.1016/s0027-5107(00)00149-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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