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Article

Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype.

Experimental cell research - 1 May 1999

Higgins P J, Slack J K, Diegelmann R F, Staiano-Coico L

Abstract excerpt

Synthesis of the major negative physiologic regulator of plasmin activation [plasminogen activator inhibitor type-1 (PAI-1)] is elevated during progressive cellular senescence, in premature aging disorders (e.g., Werner's syndrome), and in conditions associated with tissue fibrosis and excessive fibrin accumulation (e.g., sclerosis, keloid formation). Dermal fibroblasts derived from Werner's patients as well as...

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Identifiers

PMID: 10222156
DOI: 10.1006/excr.1999.4466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype.PMID 10222156Read ↗

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