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Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression

1 Jan 2003

Abstract excerpt

Age is an important factor in the development and spread of breast cancer. Stromal cells also contribute to breast cancer growth and metastasis through the production of extracellular matrix (ECM) modifiers such as urokinase type plasminogen activator (uPA), its receptor (uPAR), its inhibitors (PAI-1 and PAI-2), matrix metalloproteinases (MMPs), and growth factors, including the fibroblast and insulin-like growth...

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PMID: 12574821
DOI: 10.1055/s-0037-1613457

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