Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.

Nature cell biology - 1 Aug 2006

Kortlever Roderik M, Higgins Paul J, Bernards René

Abstract excerpt

p53 limits the proliferation of primary diploid fibroblasts by inducing a state of growth arrest named replicative senescence - a process which protects against oncogenic transformation and requires integrity of the p53 tumour suppressor pathway. However, little is known about the downstream target genes of p53 in this growth-limiting response. Here, we report that suppression of the p53 target gene encoding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cisplatin
Share to Cyclin-Dependent Kinase 4
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to NIH 3T3 Cells

Share to Plasminogen Activator Inhibitor 1

Share to Tumor Suppressor Protein p14ARF

Source

Open in PubMed Open full text

Identifiers

PMID: 16862142
DOI: 10.1038/ncb1448
PMCID: PMC2954492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.PMID 16862142Read ↗

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.Semantic proximity Read ↗

Differential growth state‐dependent regulation of plasminogen activator inhibitor type‐1 expression in senescent IMR‐90 human diploid fibroblastsSemantic proximity Read ↗

Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung diseaseSemantic proximity Read ↗

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of SenescenceSemantic proximity Read ↗

p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts.Semantic proximity Read ↗

Overexpression of plasminogen activator inhibitor type‐1 in senescent fibroblasts from normal subjects and those with Werner syndromeSemantic proximity Read ↗

Characterization of the p53 response to oncogene-induced senescence.Semantic proximity Read ↗

PAI-1: A New Target for Controlling Lung-Cell Senescence and Fibrosis?Semantic proximity Read ↗

PAI-1 contributes to homocysteine-induced cellular senescenceSemantic proximity Read ↗

Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence.Semantic proximity Read ↗

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.Semantic proximity Read ↗

TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.