Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.

doi:10.1038/ncb1448

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Article

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.

Nature cell biology - 1 Aug 2006

Kortlever Roderik M, Higgins Paul J, Bernards René

Abstract excerpt

p53 limits the proliferation of primary diploid fibroblasts by inducing a state of growth arrest named replicative senescence - a process which protects against oncogenic transformation and requires integrity of the p53 tumour suppressor pathway. However, little is known about the downstream target genes of p53 in this growth-limiting response. Here, we report that suppression of the p53 target gene encoding...

Topics

Animals
Blotting, Western
Cell Proliferation
Cells, Cultured
Cellular Senescence
Cisplatin
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
DNA Damage
Embryo, Mammalian
Fibroblasts
Glycogen Synthase Kinase 3

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycogen Synthase Kinase 3 beta

Humans

Mice

Microscopy, Fluorescence

Mutation

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Identifiers

PMID: 16862142
DOI: 10.1038/ncb1448
PMCID: PMC2954492

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