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Article

Radiation and transforming growth factor-beta cooperate in transcriptional activation of the profibrotic plasminogen activator inhibitor-1 gene.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2005

Hageman Jurre, Eggen Bart J, Rozema Tom, Damman Kevin, Kampinga Harm H, Coppes Robert P

Abstract excerpt

Radiation-induced fibrosis is an important side effect in the treatment of cancer. Profibrotic proteins, such as plasminogen activator inhibitor-1 (PAI-1), transforming growth factor-beta (TGF-beta), and tissue type inhibitor of metalloproteinases-1 (Timp-1), are thought to play major roles in the development of fibrosis via the modulation of extracellular matrix integrity. We did a detailed analysis of...

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Identifiers

PMID: 16115939
DOI: 10.1158/1078-0432.CCR-05-0427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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