Article
WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts.
BMC cardiovascular disorders - 29 Feb 2008
Castro Elena, Oviedo-Rodríguez Vladimir, Angel-Chávez Luis I
Abstract excerpt
BACKGROUND: Recessive mutations in WRN gene eliminate WRN protein function (helicase) and cause Werner syndrome. One of the most important clinical features of Werner syndrome patients are the premature onset and accelerated atherosclerosis process. Studies carried out on polymorphic WRN locus have shown that the alleles 1367R and 1074L confer protection for cardiovascular disease. Given that the levels of...
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