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Article

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

1 Aug 1991

Abstract excerpt

Genes that play a role in the senescent arrest of cellular replication are likely to be overexpressed in human diploid fibroblasts (HDF) derived from subjects with Werner syndrome (WS) because these cells have a severely curtailed replicative life span. To identify some of these genes, a cDNA library was constructed from WS HDF after they had been serum depleted and repleted (5 days in medium containing 1% serum...

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PMID: 1712899
DOI: 10.1128/mcb.11.8.3905

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Source receipt: pubmed, retrieved 7 Sept 2026.

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