Article
PRB1 is required for clipping of the histone H3 N terminal tail in Saccharomyces cerevisiae.
PloS one - 1 Jan 2014
Xue Yong, Vashisht Ajay A, Tan Yuliang, Su Trent, Wohlschlegel James A
Abstract excerpt
Cathepsin L, a lysosomal protein in mouse embryonic stem cells has been shown to clip the histone H3 N- terminus, an activity associated with gene activity during mouse cell development. Glutamate dehydrogenase (GDH) was also identified as histone H3 specific protease in chicken liver, which has been connected to gene expression during aging. In baker's yeast, Saccharomyces cerevisiae, clipping the histone H3...
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