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Article

Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning.

Development (Cambridge, England) - 1 Oct 2003

Corbin Joshua G, Rutlin Michael, Gaiano Nicholas, Fishell Gord

Abstract excerpt

Regional patterning of the mammalian telencephalon requires the function of three homeodomain-containing transcription factors, Pax6, Gsh2 and Nkx2.1. These factors are required for the development of the dorsal, lateral and medial domains of the telencephalon, respectively. Previous work has indicated that two of the genes encoding these factors, Pax6 and Gsh2, cross-repress one another in the formation of the...

Topics

Animals
Eye Proteins
Hedgehog Proteins
Homeodomain Proteins
Mice
PAX6 Transcription Factor
Paired Box Transcription Factors
Phenotype
Repressor Proteins
Telencephalon
Trans-Activators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12930780
DOI: 10.1242/dev.00717

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