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Article

Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity.

Genes & development - 1 Feb 2002

Parras Carlos M, Schuurmans Carol, Scardigli Raffaella, Kim Jaesang, Anderson David J, Guillemot François

Abstract excerpt

The neural bHLH genes Mash1 and Ngn2 are expressed in complementary populations of neural progenitors in the central and peripheral nervous systems. Here, we have systematically compared the activities of the two genes during neural development by generating replacement mutations in mice in which the coding sequences of Mash1 and Ngn2 were swapped. Using this approach, we demonstrate that Mash1 has the capacity...

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Identifiers

PMID: 11825874
DOI: 10.1101/gad.940902
PMCID: PMC155336

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Source receipt: pubmed, retrieved 7 Sept 2026.

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