Article
Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling.
Development (Cambridge, England) - 1 Dec 2004
Park Hae-Chul, Shin Jimann, Appel Bruce
Abstract excerpt
Graded Hedgehog (Hh) signaling patterns the spinal cord dorsoventral axis by inducing and positioning distinct precursor domains, each of which gives rise to a different type of neuron. These domains also generate glial cells, but the full range of cell types that any one precursor population produces and the mechanisms that diversify cell fate are unknown. By fate mapping and clonal analysis in zebrafish, we...
Topics
- Animals
- Animals, Genetically Modified
- Bromodeoxyuridine
- Cell Lineage
- Cloning, Molecular
- Gene Expression Regulation, Developmental
- Green Fluorescent Proteins
- Hedgehog Proteins
- Immunohistochemistry
- In Situ Hybridization