Article
A dominant negative mutation in the GIM1 gene of Leishmania donovani is responsible for defects in glycosomal protein localization.
Molecular and biochemical parasitology - 15 Mar 1999
Flaspohler J A, Lemley K, Parsons M
Abstract excerpt
Kinetoplastid protozoa contain a unique microbody organelle called the glycosome. Several important metabolic pathways are compartmentalized within the glycosome that are found in the cytoplasm of higher eukaryotes. We have previously reported the identification of a Leishmania donovani cell line called gim1-1, in which several normally glycosomal proteins are partially mislocalized to the cytoplasm. The GIM1...
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