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Expression of a Mutant Form of Leishmania donovani Centrin Reduces the Growth of the Parasite

1 Nov 2001

Abstract excerpt

Leishmania donovani, a protozoan parasite, causes visceral disease in humans. To identify genes that control growth, we have isolated for the first time in the order Kinetoplastida a gene encoding for centrin from L. donovani. Centrin is a calcium-binding cytoskeletal protein essential for centrosome duplication or segregation. Protein sequence similarity and immunoreactivity confirmed that Leishmania centrin is...

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PMID: 11544261
DOI: 10.1074/jbc.m106806200

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