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Article

Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: a potential glucose sensor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2015

Rodriguez-Contreras Dayana, Aslan Hamide, Feng Xiuhong, Tran Khoa, Yates Phillip A, Kamhawi Shaden, Landfear Scott M

Abstract excerpt

In Leishmania mexicana parasites, a unique glucose transporter, LmxGT1, is selectively targeted to the flagellar membrane, suggesting a possible sensory role that is often associated with ciliary membrane proteins. Expression of LmxGT1 is down-regulated ∼20-fold by increasing cell density but is up-regulated ∼50-fold by depleting glucose from the medium, and the permease is strongly down-regulated when...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25300620
DOI: 10.1096/fj.14-251991
PMCID: PMC4285543

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