Article
Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host.
Eukaryotic cell - 1 Aug 2008
Vince James E, Tull Dedreia L, Spurck Timothy, Derby Merran C, McFadden Geoffrey I, Gleeson Paul A, Gokool Suzanne, McConville Malcolm J
Abstract excerpt
The adaptor protein-1 (AP-1) complex is involved in membrane transport between the Golgi apparatus and endosomes. In the protozoan parasite Leishmania mexicana mexicana, the AP-1 mu1 and sigma1 subunits are not required for growth at 27 degrees C but are essential for infectivity in the mammalian host. In this study, we have investigated the function of these AP-1 subunits in order to understand the molecular...
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