Article
Expression of p53 family members and CD44 in oral squamous cell carcinoma (OSCC) in relation to tumorigenesis.
Histology and histopathology - 1 Mar 2010
Bidaud Pauline, Chasle Jacques, Sichel François, Rousseau Stéphane, Petit Pascal, Pottier Didier, Picquenot Jean-Michel, Louis Marie-Yolande, Lechevrel Mathilde
Abstract excerpt
Oral squamous cell carcinomas (OSCCs) are described as the result of a multistep tumorigenesis process. In order to develop useful diagnosis of pre-malignant lesions, expression of p53 family members and the cancer stem cell (CSCs) marker, CD44v6, were studied in histologically normal oral epithelium, precancerous lesions and succeeding invasive OSCCs. p53 was expressed focally in normal epithelium adjacent to...
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