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Article

Sequence uniqueness and sequence variability as modulating factors of human anti-HCV humoral immune response.

Cancer immunology, immunotherapy : CII - 1 Aug 2008

Kanduc Darja, Tessitore Luciana, Lucchese Guglielmo, Kusalik Anthony, Farber Emanuel, Marincola Francesco M

Abstract excerpt

We recently compared the HCV polyprotein to the human proteome in order to test whether amino acid sequences unique to the virus could represent immunodominant epitopic determinants of the human humoral immune response against HCV. We identified a relatively limited number of HCV fragments with no/low similarity to the human host that represented exclusive HCV motifs. In this study, the peptides corresponding to...

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Source

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Identifiers

PMID: 18256830
DOI: 10.1007/s00262-008-0456-y
PMCID: PMC11031074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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